The Hammers are in Belgium this week as they look to make it 3 wins from 3 in the UECL group stage.
Both sides have had slow starts to their league campaigns this season, but both teams are unbeaten in the group stages so far.
There are some familiar faces lining up for Anderlecht tonight, including former Tottenham captain Jan Vertonghen and Wolves loanee Fabio Silva.
The Belgian side are yet to concede in this year's group stage after 2 games, and will have a tough task to continue this record tonight.
West Ham will hope they can build on a big win at the weekend, as they picked up their second league 3 points after beating Wolves 2-0.
David Moyes has an almost full squad available to him for the game tonight, with Maxwel Cornet one of the two players not to travel with the squad following his calf injury at the weekend.
Nayef Aguerd yet again misses a match, but he is nearing full fitness and should be available for selection soon.
When asked about tonight’s opponents, David Moyes told the media, “I wouldn’t in any way disrespect Anderlecht”. “They will want to win, they see a chance to try and get above us”.
The game kicks off at 5:45pm and is available to watch on BT Sport.