After losing in the North London Derby earlier in the season, Tottenham are looking for revenge with Harry Kane on the brink of becoming the Lilywhites' all-time top goalscorer.
The league leaders, Arsenal, are on top form at the moment and are five points ahead of Manchester City, who are looking for their third Premier League title in a row.
Antonio Conte's Spurs side, on the other hand, struggled for form upon their return from the World Cup break, gaining only one point against Aston Villa and Brentford.
However, Harry Kane, following an FA Cup goal against Portsmouth, only requires a brace against the Gunners to become the all-time top goalscorer in Tottenham Hotspur's history.
Kane has scored the most amount of goals in the history of this fixture and scoring just once will take his tally to 266 goals for the club, bringing him level with Jimmy Greaves.
The side from N17 are also hoping to see Rodrigo Bentancur, Richarlison and Dejan Kulusevski return to the squad, with the Swede resuming outdoor training earlier this week.
The Gunners are still without Gabriel Jesus after his injury at the World Cup, however Bukayo Saka who went off injured against Oxford United is likely to be fit.
Arsenal also have the returning Emile Smith-Rowe available for selection after he made a brief cameo in the FA Cup.
With a lot on the line for both sides, Antonio Conte is urging the Spurs fans to deliver an atmosphere reminiscent of the two sides' last encounter at the Tottenham Hotspur Stadium.
"We know very well the importance of this game from the fans, the rivalry. I remember last season a fantastic atmosphere in this game and I expect the same again."
It will be a repeat of the last North London Derby that Tottenham will be hoping for, where as Mikel Arteta's men will be hoping to complete the double after a 3-1 home victory earlier in the season.
Will Conte's side throw cold water on Arsenal's hot streak or will the visitors gun down their local rivals and continue their charge to the title.